検索結果

Search Results for " signaling pathway "

ターゲット

Gamma-secretase

235

阻害剤

天然化合物

154

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T12246	CB-103		Gamma-secretase
	CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.		Gamma-secretase
T5486	RU.521	RU320521	DNA , cGAS
	RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.		DNA , cGAS
T9105	NF-κB-IN-1	1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK , NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...		IκB/IKK , NF-κB
T37538	Amifostine thiol
	Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3].
T60055	Chromeceptin	2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile	Akt , IGF-1R , mTOR
	Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.		Akt , IGF-1R , mTOR
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T67866	YW2036		Wnt/beta-catenin
	YW2036 is an inhibitor of Wnt signaling pathway.		Wnt/beta-catenin
T5129	SRI-011381 hydrochloride	SRI-011381 hydrochloride [1629138-41-5(free base)]	TGF-beta/Smad
	SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T4662	SJ000291942		TGF-beta/Smad
	SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.		TGF-beta/Smad
T15019	CUR61414		Hedgehog/Smoothened
	CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).		Hedgehog/Smoothened
T39823L	Apelin-12 acetate	Apelin-12 acetate (229961-08-4 Free base)	Apelin receptor , p38 MAPK , JNK
	Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.		Apelin receptor , p38 MAPK , JNK
TP1367	[D-Ala2]leucine-enkephalin		Opioid Receptor
	[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.		Opioid Receptor
T26193	SKLB-163	SKLB163	MAPK , Akt , Caspase , Rho , JNK
	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.		MAPK , Akt , Caspase , Rho , JNK
T24642	YH-306	YH306,TRV055 acetate (25849-90-5 Free base)	MMP , MMP , FAK , Rho , PI3K , Src
	YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.		MMP , MMP , FAK , Rho , PI3K , Src
T50107	Ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate		Others
	ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through ...		Others
T22884	JW 67		Wnt/beta-catenin
	JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.		Wnt/beta-catenin
T10655	C-Met inhibitor 1		c-Met/HGFR
	c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.		c-Met/HGFR
T23861	CAY10526	CAY-10526,BTH,CAY 10526	Prostaglandin Receptor
	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.		Prostaglandin Receptor
T37422L	Ras Inhibitory Peptide acetate	Ras Inhibitory Peptide acetate(159088-48-9 Free base)	Ras
	Ras Inhibitory Peptide acetate is a peptide involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic receptors.		Ras
T3156	Ciliobrevin A	Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened
	Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.		Hedgehog/Smoothened
T8917	PAR-2-IN-1	IUN76750	Protease-activated Receptor
	PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.		Protease-activated Receptor
T4022	QS11	QS 11	GTPase
	QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r...		GTPase
T4283	SRI-011381		TGF-beta/Smad
	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T3705	GDC0084	GDC-0084,RG7666,GDC 0084	PI3K , mTOR
	GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation o...		PI3K , mTOR
T1957	AZD2858		GSK-3
	AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.		GSK-3
T7204	PNU-74654		Apoptosis , Wnt/beta-catenin
	PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.		Apoptosis , Wnt/beta-catenin
TP1215L	Abaloparatide acetate(247062-33-5 free base)		Others
	Abaloparatide acetate is a parathyroid hormone receptor 1 PTHR1 analogue and an effective and selective activator of the PTHR1 signaling pathway.		Others
T9151	Teplinovivint		Wnt/beta-catenin
	Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.		Wnt/beta-catenin
T27034	CL075	3M002,CL-075	NF-κB , TLR , MyD88
	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i...		NF-κB , TLR , MyD88
T11571	HLY78	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.		Wnt/beta-catenin
T60929	Brassinazole	(2S,3R)-Brassinazole	Others
	Brassinazole is a selective inhibitor of triazole-type steroid (BR) biosynthesis.Brassinazole can be used to modulate the oleuropein steroid (BR) signaling pathway, which is used to regulate plant xylem growth and develo...		Others
T9500	M435-1279		E1/E2/E3 Enzyme
	M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.		E1/E2/E3 Enzyme
TQ0133	Amifostine thiol dihydrochloride	WR 1065	p53
	Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.		p53
T1970	Gedatolisib	PF-05212384,PKI-587	PI3K , mTOR
	Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.		PI3K , mTOR
T1807	JW 55	JW55	PARP , Wnt/beta-catenin
	JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).		PARP , Wnt/beta-catenin
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal...
T76749	Zilovertamab	Cirmtuzumab,UC-961	Others
	Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity in ovarian and endometrial cancer cells. It can be used to s...		Others
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T9196	IACS-13909	BBP-398	Phosphatase
	IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.		Phosphatase
T64351	GI-560192	RL-0070933	Smo
	GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.		Smo
T40465	SAG dihydrochloride		Hedgehog/Smoothened
	SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.		Hedgehog/Smoothened
T35528L	TD52 dihydrochloride	TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali...		Others
T1779	SAG	Smoothened Agonist (SAG) HCl,Smoothened Agonist	Hedgehog/Smoothened , Smo
	SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.		Hedgehog/Smoothened , Smo
T22775	Exo-IWR-1	exo-IWR 1	Wnt/beta-catenin
	exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.		Wnt/beta-catenin
T15019L	CUR61414 hydrochloride	CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened
	CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively...		Hedgehog/Smoothened
T3162	IDE1		Others
	IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50: 125.5 nM...		Others
T20435L	Leuphasyl TFA		Opioid Receptor
	Leuphasyl TFA is an amid peptide, a δ-opioid receptor agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid receptors. Leuphasyl TFA is a potent, long-a...		Opioid Receptor
T36527	IL-4-inhibitor-1		IL Receptor
	IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib...		IL Receptor
T50050	2,3-dihydroxy-3-methylbutanoic acid		Others
	2,3-dihydroxy-3-methylbutanoic acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakd...		Others
T39988	6'-GNTI dihydrochloride		Opioid Receptor , Akt
	6'-GNTI dihydrochloride is a κ-opioid receptor (KOR) agonist that favors activation of G-protein-mediated signaling over recruitment of β-aspirin 2. 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neur...		Opioid Receptor , Akt

Compounds

CB-103

T12246

Synonym:

Target: Gamma-secretase

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

Synonym: 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile

Target: Akt, IGF-1R, mTOR

Copanlisib

T6322

Synonym: BAY 80-6946

Target: Apoptosis, PI3K

YW2036

T67866

Synonym:

Target: Wnt/beta-catenin

SRI-011381 hydrochloride

T5129

Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]

Target: TGF-beta/Smad

SJ000291942

T4662

Synonym:

Target: TGF-beta/Smad

CUR61414

T15019

Synonym:

Target: Hedgehog/Smoothened

Apelin-12 acetate

T39823L

Synonym: Apelin-12 acetate (229961-08-4 Free base)

Target: Apelin receptor, p38 MAPK, JNK

[D-Ala2]leucine-enkephalin

TP1367

Synonym:

Target: Opioid Receptor

SKLB-163

T26193

Synonym: SKLB163

Target: MAPK, Akt, Caspase, Rho, JNK

YH-306

T24642

Synonym: YH306,TRV055 acetate (25849-90-5 Free base)

Target: MMP, MMP, FAK, Rho, PI3K, Src

ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

Target: Wnt/beta-catenin

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Ras Inhibitory Peptide acetate

T37422L

Synonym: Ras Inhibitory Peptide acetate(159088-48-9 Free base)

Target: Ras

Ciliobrevin A

T3156

Synonym: Hedgehog Pathway Inhibitor 4,HPI-4

Target: Hedgehog/Smoothened

PAR-2-IN-1

T8917

Synonym: IUN76750

Target: Protease-activated Receptor

Target: TGF-beta/Smad

GDC0084

T3705

Synonym: GDC-0084,RG7666,GDC 0084

Target: Apoptosis, Wnt/beta-catenin

Abaloparatide acetate(247062-33-5 free base)

Target: Wnt/beta-catenin

CL075

T27034

Synonym: 3M002,CL-075

Target: NF-κB, TLR, MyD88

HLY78

T11571

Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Target: Wnt/beta-catenin

Brassinazole

T60929

Synonym: (2S,3R)-Brassinazole

Target: E1/E2/E3 Enzyme

Amifostine thiol dihydrochloride

Synonym: PF-05212384,PKI-587

Target: PARP, Wnt/beta-catenin

Synonym: Cirmtuzumab,UC-961

Target: Hedgehog/Smoothened

Target: Hedgehog/Smoothened

TD52 dihydrochloride

T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

SAG

T1779

Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist

Target: Hedgehog/Smoothened, Smo

exo-IWR-1

T22775

Synonym: exo-IWR 1

Target: Wnt/beta-catenin

CUR61414 hydrochloride

T15019L

Synonym: CUR61414 hydrochloride (334998-36-6 Free base)

Target: Hedgehog/Smoothened

Target: Opioid Receptor

2,3-dihydroxy-3-methylbutanoic acid

T50050

Synonym:

Target: Others

6'-GNTI dihydrochloride

T39988

Synonym:

Target: Opioid Receptor, Akt

カタログ番号	製品名	別名	ターゲット
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
TN6739	Angoline	6-Methoxyldihydrochelerythrine	IL Receptor , STAT
	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can...		IL Receptor , STAT
T4S0544	Furanodienone		Apoptosis , HER
	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependen...		Apoptosis , HER
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
T2789	Scutellarin	Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt , HIV Protease , STAT
	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal...		Akt , HIV Protease , STAT
T13803	N-Oleoyl glycine		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
TQ0183	Narciclasine	Lycoricidinol	ROCK
	Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.		ROCK
T7982	3,6-Dihydroxyflavone		Others
	3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.		Others
T83321	4-Demethyldeoxypodophyllotoxin		Chk
	4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.		Chk
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
T5793	Britannin		Apoptosis , AMPK , Autophagy
	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.		Apoptosis , AMPK , Autophagy
T6S0107	Peimine	Wanpeinine A,Dihydroisoimperialine,Verticine	Others
	1. Peimine (Wanpeinine A) has good anti-inflammatory effects in vivo. 2. Peimine is an inhibitor to inhibit LPS-induced production of inflammatory cytokines by blocking the MAPKs and NF-κB signaling pathway.		Others
T3759	3,4-Dimethoxycinnamic acid	Dimethylcaffeic acid,Caffeic acid dimethyl ether,O-Methylferulic acid	Apoptosis , Virus Protease , Reactive Oxygen Species
	3,4-Dimethoxycinnamic acid (O-Methylferulic acid) (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated...		Apoptosis , Virus Protease , Reactive Oxygen Species
TN1833	Karacoline		NF-κB
	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.		NF-κB
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T2896	Alantolactone	helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor	Apoptosis , STAT , TGF-beta/Smad
	Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3...		Apoptosis , STAT , TGF-beta/Smad
TN1077	Taraxerol	Skimmiol,Alnulin	Apoptosis , NF-κB
	Taraxerol(Alnulin) is an anti-inflammatory and anticancer compound derived from dandelion.Taraxerol reduces acute inflammation and induces apoptosis by inhibiting the NF-κB signaling pathway.		Apoptosis , NF-κB
T3418	Demethylzeylasteral	Demethylzeylasteral (T-96)	Apoptosis , UGT
	Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signal...		Apoptosis , UGT
T5729	L-quebrachitol		Wnt/beta-catenin
	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.		Wnt/beta-catenin
TN1236	3',4',7-Trihydroxyisoflavone		MAPK , JNK
	3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan...		MAPK , JNK
T6S0234	Toosendanin		Others
	1. Toosendanin possesses hepatotoxicity. 2. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. 3. Toosendanin i...		Others
T3925	Astragaloside I	Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin
	Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen...		Wnt/beta-catenin
TN1507	Clematichinenoside AR		TNF , Autophagy
	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.		TNF , Autophagy
T7033	Rosmanol		Antioxidant , COX
	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...		Antioxidant , COX
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T5120	Rhamnose	6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel , Endogenous Metabolite
	Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind...		Calcium Channel , Endogenous Metabolite
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide	(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14	Wnt/beta-catenin
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...		Wnt/beta-catenin
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
TN1557	Decursinol angelate		ERK , VEGFR , PKC , JNK
	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...		ERK , VEGFR , PKC , JNK
T5S0896	Loureirin A		Akt , PI3K
	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept...		Akt , PI3K
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
TN1015	Meranzin		Adrenergic Receptor , Immunology/Inflammation related
	Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1/2–BDNF si...		Adrenergic Receptor , Immunology/Inflammation related
T5716	4'-Methoxyresveratrol	4'-O-Methylresveratrol	advanced glycation end products
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced...		advanced glycation end products
T2S0618	β-Elemonic Acid	3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid	Apoptosis , Reactive Oxygen Species , COX
	β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel...		Apoptosis , Reactive Oxygen Species , COX
T5S1982	Periplocin	Periplocoside	Apoptosis , Others
	1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato...		Apoptosis , Others
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T3S1701	Dihydrocurcumin		PPAR , Fatty Acid Synthase
	Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, incr...		PPAR , Fatty Acid Synthase
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T4S1419	(±)-Praeruptorin A	Praeruptorin A,(-)-Praeruptorin A	p38 MAPK , Calcium Channel , Akt
	1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ...		p38 MAPK , Calcium Channel , Akt
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T6S1369	Vitexin	Apigenin-8-C-glucoside	Antioxidant
	1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit...		Antioxidant
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
------------------------ More ------------------------

天然物製品

Synonym: 6-Methoxyldihydrochelerythrine

Target: IL Receptor, STAT

Furanodienone

T4S0544

Synonym:

Target: Apoptosis, HER

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Scutellarin

T2789

Synonym: Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

N-Oleoyl glycine

T13803

Synonym:

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Narciclasine

TQ0183

Synonym: Lycoricidinol

4-Demethyldeoxypodophyllotoxin

Target: LDL, AMPK, PPAR

Britannin

T5793

Synonym:

Target: Apoptosis, AMPK, Autophagy

Peimine

T6S0107

Synonym: Wanpeinine A,Dihydroisoimperialine,Verticine

Target: Others

3,4-Dimethoxycinnamic acid

T3759

Synonym: Dimethylcaffeic acid,Caffeic acid dimethyl ether,O-Methylferulic acid

Target: Apoptosis, Virus Protease, Reactive Oxygen Species

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Alantolactone

T2896

Synonym: helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

Taraxerol

TN1077

Synonym: Skimmiol,Alnulin

Target: Apoptosis, NF-κB

Demethylzeylasteral

T3418

Synonym: Demethylzeylasteral (T-96)

Target: Apoptosis, UGT

L-quebrachitol

T5729

Synonym:

Target: Wnt/beta-catenin

3',4',7-Trihydroxyisoflavone

Synonym: Cyclosieversioside B,Astrasieversianin IV

Target: Wnt/beta-catenin

Clematichinenoside AR

TN1507

Synonym:

Target: TNF, Autophagy

Rosmanol

T7033

Synonym:

Target: Antioxidant, COX

(-)-Butin

TN1461

Synonym: Butin

Target: Akt, PI3K, Nrf2

Cyasterone

T3870

Synonym: Cyasteron

Target: Apoptosis, EGFR

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Rhamnose

T5120

Synonym: 6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose

Target: Calcium Channel, Endogenous Metabolite

Cucurbitacin B

T3404

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14

Target: Wnt/beta-catenin

Onjisaponin B

TN1140

Synonym:

Target: AMPK, mTOR, Autophagy

Decursinol angelate

TN1557

Synonym:

Target: ERK, VEGFR, PKC, JNK

Target: NF-κB, TLR, Akt, PI3K

Meranzin

TN1015

Synonym:

Target: Adrenergic Receptor, Immunology/Inflammation related

4'-Methoxyresveratrol

T5716

Synonym: 4'-O-Methylresveratrol

Target: advanced glycation end products

β-Elemonic Acid

T2S0618

Synonym: 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid

Target: Apoptosis, Reactive Oxygen Species, COX

Periplocin

T5S1982

Synonym: Periplocoside

Target: Apoptosis, Others

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Target: Wnt/beta-catenin, Glucosidase

Brazilin

T6S1784

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Target: PPAR, Fatty Acid Synthase

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

(±)-Praeruptorin A

T4S1419

Synonym: Praeruptorin A,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Vitexin

T6S1369

Synonym: Apigenin-8-C-glucoside

Target: Apoptosis, BCL, COX, UGT

--------- More ---------

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01174	DKK1 Protein, Rhesus, Recombinant (N256Q, His)	Rhesus	HEK293 Cells
	DKK1 Protein, Rhesus, Recombinant (N256Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.2 kDa and the accession number is XP_001098844.1.
TMPY-04811	DKK1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DKK1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.6 kDa and the accession number is O54908.
TMPY-00775	DKK1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DKK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.22 kDa and the accession number is I1W660.
TMPY-01121	DKK3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DKK3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q9QUN9.
TMPY-05797	DKK1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	DKK1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.44 kDa and the accession number is A6I0Z0.
TMPY-01175	DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)	Rhesus	HEK293 Cells
	DKK1 Protein, Rhesus, Recombinant (N256Q, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 53.5 kDa and the accession number is XP_001098844.1.
TMPY-06377	DKK3 Protein, Human, Recombinant	Human	HEK293 Cells
	DKK3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.29 kDa and the accession number is Q9UBP4.
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such...
TMPY-05479	DKK1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DKK1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is I1W660.
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPK-00369	HGF Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different i...
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth an...
TMPY-05176	AMH Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and ...
TMPH-01274	ZNRF3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can...
TMPH-01275	ZNRF3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can...
TMPH-02284	USP26 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPH-01548	IFI6 Protein, Human, Recombinant (B2M & His)	Human	E. coli
	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towar...
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPK-00696	PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)	Human	Baculovirus Insect Cells
	The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPH-01662	Merlin Protein, Human, Recombinant (His)	Human	E. coli
	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergisti...
TMPH-02104	Sestrin-3/SESN3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may al...
TMPH-02612	CXCR3 Protein, Mouse, Recombinant (His & KSI)	Mouse	E. coli
	Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell c...
TMPJ-01373	DKK3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dickkopf-related protein 3 (DKK3) belongs to the DKK protein family including Dkk-1, 2, 3 and -4. DKK3 is a 350 amino acid secreted glycoprotein which is comprised of an N-terminal signal peptide and 2 conserved cysteine...
TMPH-03265	CMKLR2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to...
TMPH-02273	JAK1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPH-01611	LGR6 Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with pho...
TMPH-01825	NOTUM Protein, Human, Recombinant (His)	Human	E. coli
	Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient bindin...
TMPH-02156	SOCS1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02271	BTK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPH-01422	GNAS Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting...
TMPY-02964	Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle...
TMPH-03365	REG3A Protein, Rat, Recombinant (E.coli, His)	Rat	E. coli
	Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. ...
TMPK-00774	TrkA Protein, Human, Recombinant (aa 33-417, His)	Human	HEK293 Cells
	TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa...
TMPH-01988	TDGF1P3 Protein, Human, Recombinant (His)	Human	E. coli
	Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway. TDGF1P3 Protein, Human, Recombinant (His) is expressed in E. co...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro...
TMPH-01539	ILK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E...
TMPH-02864	Wnt1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is ...
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but ...
TMPK-00428	HER2/ErbB2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t...
TMPH-02865	Wnt3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal ...
TMPJ-00433	VSIR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling...
TMPK-00868	Notch 4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression ...
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01550	Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pa...
TMPH-02861	Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d...
TMPK-01203	TNFRSF19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for na...
------------------------ More ------------------------

DKK1 Protein, Rhesus, Recombinant (N256Q, His)

TMPY-01174

Species: Rhesus

Expression System: HEK293 Cells

DKK1 Protein, Mouse, Recombinant (His)

TMPY-04811

Species: Mouse

Expression System: HEK293 Cells

DKK1 Protein, Human, Recombinant (His)

TMPY-00775

Species: Human

Expression System: HEK293 Cells

DKK3 Protein, Mouse, Recombinant (His)

TMPY-01121

Species: Mouse

Expression System: HEK293 Cells

DKK1 Protein, Rat, Recombinant (His)

TMPY-05797

Species: Rat

Expression System: HEK293 Cells

DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)

TMPY-01175

Species: Rhesus

Expression System: HEK293 Cells

DKK3 Protein, Human, Recombinant

TMPY-06377

Species: Human

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

TMPY-00950

Species: Human

Expression System: HEK293 Cells

DKK1 Protein, Human, Recombinant (hFc)

TMPY-05479

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

TMPY-02028

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Mouse, Recombinant (His)

TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (hFc)

TMPK-00369

Species: Human

Expression System: HEK293 Cells

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

TMPY-01355

Species: Human

Expression System: Baculovirus Insect Cells

AMH Protein, Human, Recombinant (His)

TMPY-05176

Species: Human

Expression System: HEK293 Cells

ZNRF3 Protein, Human, Recombinant (His & SUMO)

TMPH-01274

Species: Human

Expression System: E. coli

ZNRF3 Protein, Human, Recombinant (His)

TMPH-01275

Species: Human

Expression System: HEK293 Cells

USP26 Protein, Human, Recombinant (His)

TMPH-02284

Species: Human

Expression System: E. coli

IFI6 Protein, Human, Recombinant (B2M & His)

TMPH-01548

Species: Human

Expression System: E. coli

RNF43 Protein, Mouse, Recombinant (hFc)

TMPK-01001

Species: Mouse

Expression System: HEK293 Cells

JAK1 Protein, Human, Recombinant (E. coli, His)

TMPH-02272

Species: Human

Expression System: E. coli

PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)

TMPK-00696

Species: Human

Expression System: Baculovirus Insect Cells

Merlin Protein, Human, Recombinant (His)

TMPH-01662

Species: Human

Expression System: E. coli

Sestrin-3/SESN3 Protein, Human, Recombinant (His & Myc)

TMPH-02104

Species: Human

Expression System: E. coli

CXCR3 Protein, Mouse, Recombinant (His & KSI)

TMPH-02612

Species: Mouse

Expression System: E. coli

DKK3 Protein, Human, Recombinant (His)

TMPJ-01373

Species: Human

Expression System: HEK293 Cells

CMKLR2 Protein, Rat, Recombinant (His)

TMPH-03265

Species: Rat

Expression System: E. coli

GRK2 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02540

Species: Mouse

Expression System: E. coli

JAK1 Protein, Human, Recombinant (His)

TMPH-02273

Species: Human

Expression System: P. pastoris (Yeast)

LGR6 Protein, Human, Recombinant (His)

TMPH-01611

Species: Human

Expression System: E. coli

NOTUM Protein, Human, Recombinant (His)

TMPH-01825

Species: Human

Expression System: E. coli

SOCS1 Protein, Human, Recombinant (His)

TMPH-02156

Species: Human

Expression System: P. pastoris (Yeast)

BTK Protein, Human, Recombinant (His)

TMPH-02271

Species: Human

Expression System: Baculovirus Insect Cells

GNAS Protein, Human, Recombinant (His & SUMO)

TMPH-01422

Species: Human

Expression System: E. coli

Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)

TMPY-02964

Species: Human

Expression System: Baculovirus Insect Cells

REG3A Protein, Rat, Recombinant (E.coli, His)

TMPH-03365

Species: Rat

Expression System: E. coli

TrkA Protein, Human, Recombinant (aa 33-417, His)

TMPK-00774

Species: Human

Expression System: HEK293 Cells

TDGF1P3 Protein, Human, Recombinant (His)

TMPH-01988

Species: Human

Expression System: E. coli

PRKG1 Protein, Human, Recombinant (His)

TMPJ-01112

Species: Human

Expression System: HEK293 Cells

ILK Protein, Human, Recombinant (His)

TMPH-01539

Species: Human

Expression System: Baculovirus Insect Cells

ULBP-2 Protein, Human, Recombinant (His & Avi)

TMPK-00136

Species: Human

Expression System: HEK293 Cells

Wnt1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02864

Species: Mouse

Expression System: E. coli

JAK1 Protein, Mouse, Recombinant (His)

TMPH-02961

Species: Mouse

Expression System: E. coli

HER2/ErbB2 Protein, Human, Recombinant (His & Avi)

TMPK-00428

Species: Human

Expression System: HEK293 Cells

Wnt3 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02865

Species: Mouse

Expression System: E. coli

VSIR Protein, Cynomolgus, Recombinant (His)

TMPJ-00433

Species: Cynomolgus

Expression System: HEK293 Cells

Notch 4 Protein, Mouse, Recombinant (His)

TMPK-00868

Species: Mouse

Expression System: HEK293 Cells

SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01702

Species: Human

Expression System: E. coli

Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO)

TMPH-01550

Species: Human

Expression System: E. coli

Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)

TMPH-02861

Species: Mouse

Expression System: E. coli

TNFRSF19 Protein, Human, Recombinant (hFc)

TMPK-01203

Species: Human

Expression System: HEK293 Cells

--------- More ---------

カタログ番号	製品名
L8500	HIF-1 Signaling Pathway Compound Library	1336 compounds
	A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L1310	Cytoskeletal Signaling Pathway Compound Library	759 compounds
	A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS；
L4300	Wnt/Hedgehog/Notch Compound Library	237 compounds
	A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L1300	PI3K-AKT-mTOR Compound Library	420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L3700	JAK-STAT Compound Library	252 compounds
	A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L8700	Ferroptosis Compound Library	779 compounds
	A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L1120	AMPK-Targeted Compound Library	80 compounds
	80 well-chosen unique AMPK-targeted small molecules；
L2193	Anti-Liver Cancer Compound Library	1787 compounds
	1787 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.
L4020	NO PAINS Compound Library	9384 compounds

L1580	GPCR Compound Library Plus	338 compounds
	Well-chosen 338 GPCR targeting compounds with unique structures;
L2191	Anti-Breast Cancer Compound Library	1939 compounds
	A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study；
L6750	PBCRBS Traditional Chinese Medicine Compound Library	580 compounds
	A unique collection of 580 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.
L8110	Reprogramming Compound Library	1813 compounds
	A unique collection of 1813 reprogramming signaling pathway-related bioactive small molecule compounds for high-throughput, high-content screening.
L9700	Endoplasmic Reticulum Stress Compound Library	193 compounds
	A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
L2550	Glutamine Metabolism Compound Library	565 compounds
	A unique collection of 565 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...